Edmundo N. Kraiselburd, Ph.D.

Educational Background:

  • M.S. Nuclear Physics, Universidad de Buenos Aires, 1965

  • M.S. Molecular Biology, State Univ. of New York at Buffalo, 1971

  • Ph. D. Virology, State Univ. of New York at Buffalo, 1973

Academic Position:

  • Professor & Director Unit of Comparative Medicine

  • Director Caribbean Primate Research Center & Director SNRP NeuroAIDS Research Program

Academic Address, Telephone & E-Mail:

Dept. of Microbiology and Zoology
University of Puerto Rico-School of Medicine
P.O. Box 365067, San Juan, P.R. 00936-5067.
Phone: (787)758-2525 ext.1324
Direct:(787)764-4325 o (787)777-0079
Fax: (787) 777-0078
E-mail: ekraiselburd@rcm.upr.edu

Field of Interest:

Basic Research in SIV/HIV vaccines:

  1. Evaluation Studies of a DNA Vaccine Expressing SIVsm VLP: The long term objective of this research is to develop a vaccine capable of inducing protective immune responses in rhesus macaques against pathogenic simian immunodeficiency virus (SIV). For this purpose, we are evaluating the immune responses generated in macaques by different SIV DNA vaccine (Vec B7). The 1.6Kb deletion (Dpol, vif, vpr, and vpx) of SIVsmB7 provirus DNA was introduced into the SIVsmh2 DNA to construct the Vec B7 expression vector. Vec B7 expressed SIVsm gag, env and nef proteins, produced virus-like particles (VLP) in vitro, and was immunogenic in mice. This project is supported by several grants including RO1 AI 44592 from NIH (NIAID).

Caribbean Primate Research Center:

1. Caribbean Primate Research Center Program:

The major goal of this project is to maintain and enhance the Caribbean Primate Research Center basic infrastructure, which is needed for the support of several biomedical research initiatives of national interest. This program is currently supported by a P40 RR03640 grant from NCRR (NIH); 09/30/2005 - 07/31/2010.$ 8,356,985

2. CPRC SPF Rhesus Monkey Program:

This program is currently supported by two different grants from NCRR (NIH): U42 RR016021-06A1 06/30/06-03/31/2011. $ 4,738,220 and U24 RR18108 09/30/02-08/31/07. $7,210,110

The major goal of these two projects is to develop a colony of specific pathogen-free rhesus macaques to make them available to investigators supported by NIH and by other federal programs.

NeuroAIDS Research Program:

1. Immunopathogenesis of HIV Neurological Disorders:

The major goal of this proposal is to help develop the NeuroAIDS Research Infrastructure at the UPR Medical Sciences Campus. This program is currently supported by a U54 NS43011 grant from NINDS; 09/30/01-08/31/06. $ 5,991,367

Selected Publications (2000 - Present):

  1. Eduardo O’Neill, Vanda Bostik, David C. Montefiori, Edmundo Kraiselburd, and François Villinger.IL-12/GM-CSF Co-Administration In An SIV DNA Prime/Protein Boost Protocol Enhances Gag Specific T Cells But Not Virus-Specific Neutralizing Antibodies In Rhesus Macaques. AIDS Research & Human Retroviruses AIDS Vol. 19 Issue 10. October, 2003

  2. Jensen, K., Alvarado-Remy, F., Gonzalez-Martinez, J., Kraiselburd, E., and Rulluan, J. B Virus and Free-Ranging Macaques, Puerto Rico. Emerging Infectious Diseases. Mar;10(3):494-6; 2004.

  3. Wojna V, Carlson KA, Luo X, Mayo R, Melendez LM, Kraiselburd, E. Gendelman HE. Proteomic fingerprinting of HIV-associated dementia from patient Monocyte-derived macrophages. A case study. Journal of Neurovirology. Volume 10, Supplement 1; 2004

  4. Kumar, R., Perez-Casanova, A.E., Tirado, G., Noel, R.J., Torres, C., Rodriguez, I., Martinez, M., Staprans, S., Kraiselburd, E., Yamamura, Y., Higley, J.D., and Kumar, A. Increased viral replication in Simian Immunodeficiency Virus/Simian-HIV-Infected macaques with self-administering model of chronic alcohol consumption. J Acquir Immune Defic Syndr. Volume 39, Number 4, August 1, 2005.

  5. Ellenberger, D., Wyatt, L., Li, B., Buge, S., Lanier, N., Rodriguez, I.V., Sariol, C.A., Martinez, M., Monsour, M., Dowd, J., Smith, J., Otten, R., Montefiori, D., Kraiselburd, E., Moss, B., Robinson, H., McNicholl, J., and Butera, S. Comparative immunogenicity in rhesus monkeys of multi-protein 3 HIV-1 (CRF02_AG) DNA/MVA vaccines expressing 4 mature and immature VLPs. Virology, 340(1):21-32; Sep 15, 2005.

  6. Sariol, C., Arana, T., Gerald, M.S., Maldonado, E., Gonzalez, J., Rodriguez, M., and Kraiselburd, E. Herpes-B virus seroreactivity in a colony of Macaca mulatta: Data from the Sabana Seca Field Station, a new Specific-Pathogen-Free Program. J Med Primatol; 34:13–19, 2005.

  7. Waitt, C., Gerald, M.S., Little, A.C., and Kraiselburd, E. Selective attention toward female secondary sexual color in male rhesus macaques. American Journal of Primatology. Volume 68, Issue 7, Pages: 738-744. July 2006.

SUBMITTED FOR PUBLICATION:

  1. Sariol, C.A., Arana, T., Gascot, S., Suárez, E., Rodríguez, M., Maldonado, E., González-Martínez, J., and Kraiselburd, E. Differential Distribution of Antibodies to Different Viruses in the Free-Ranging Rhesus Macaques of Cayo Santiago. Submitted, JMP.

  2. Ellenberger, D., Otten, R., Li, B., Rodriguez, I.V., Sariol, C.A., Martinez, M., Monsour, M., Wyatt, L., Hudgens, M.G., Kraiselburd, E., Moss, B., Folks, T., Robinson, H., and Butera, S. Repeated mucosal SHIV challenges of macaques after HIV-1 vaccination provides evidence of protection consistent with a leaky vaccine effect HIV-1 vaccination-elicited protection from infection. Submitted, Plos Pathogens.

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