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Child Neurology Section Research Program

Marisel Vazquez, MD
Assistant  Professor
Section Chair
Department of Pediatrics
School of Medicine
University of Puerto Rico
Tel – 787-756-4020

Email -  marisel.vazquez1@upr.edu

Research Activities:

Marisel Vázquez, M.D.

Academic Rank: Assistant Professor,
School of Medicine,
University of Puerto Rico
Administrative title - Neurology Section and Program Director  

Office Address:

Hospital Dr. Antonio Ortiz
Pediatric Department,
Call Box 191079, San  Juan, PR 00919-1079                                                                                                    
Phone: 787-756-4020

 Email: marisel.vazquez1@upr.edu

Research interest:
Neonatal Neurology , Neonatal seizures , Infantile Spasm, Autism

Research in progress; 

• 2011-present .Treatment Response and Neurodevelopmental Outcome in Patients with Infantile Spasms . Vazquez M, Gonzalez J.

• 2007-present. HIV/AIDS Cohort Study (PHACS)  Surveillance Monitoring for ART Toxicities Studies in HIV uninfected children Born to HIV infected Mothers (SMARTT Study). Position; Neurology Consultant. Source of funding; Sponsor by National Institute of Child Health and Development. (SJH 2007-2010) (RCM 2011-present)

Research Projects Participation

• 2007-present. HIV/AIDS Cohort Study (PHACS)  Surveillance Monitoring for ART Toxicities Studies in HIV uninfected children Born to HIV infected Mothers (SMARTT Study). Position; Neurology Consultant. Source of funding; Sponsor by National Institute of Child Health and Development. (SJH 2007-2010) (RCM 2011-present)

• 03/2006-03/2007 An Open-label multicentric study of the long-term safety of Depakote sprinkle capsules in the treatment of partial seizures in children, Multicentric/local PI, San Juan City Hospital

• 2005-2007. Grant HRSA : For the development of Child Neurology Training Program in P.R. Position: Clinical Investigator (PI Dra. Gregory Health Department) .Source of funding; HRSA

• 1992-2002.Prospective Study Federal Grant“Early Intenvention in Neonatal Seizures” HSJ .Funding Grant; “Consejo Estatal de Deficiencies en el Desarrollo”

• 2002-2004.Profile of learning Disability in Adolescents with Juvenile Delincuency Problems”- PI: Dr.Linares RCM. M Vazquez ;Consultant, evaluator  and Development  of the Neurology protocol.Funding; Federal Educational Dpt.

• 2004-2005.Preschool detection of risk for Learning disability .-PI; Dr. Linares –RCM. -Participation; Child Neurology Consultant ; Development of Neurology protocol and evaluator Funding; Federal Educational Dpt Grant .

• 1993-1999. “Neurologic manifestations of Puertorrican Pediatric patients with HIV” .Medical Student Investigational Study during Summer rotation.  Fraga I, Vazquez M. -Prize; Ramon Ruiz Arnau to Ivonne Fraga Medical School  prize. class 1995

Presentations:

• 40Th Child Neurology Society Annual Meeting, Savannah Georgia. October 27, 2011. No Association between C677T MTHFR gene polymorphism and Autism Spectrum Disorders among children in Puerto Rico. Montalvo-Ortiz Jocelyn,Collazo Madeline,Echegaray Marcos,Oliveras Rentas Rafael,Deliz Laura,Vazquez Correa Marisel,Carlo Simon,NEgroni Xamayta,Hernandez Yanira, Acevedo Summer

• XX Annual Research and Educational Forum –UPR School of Medicine 2011.Poster; Descriptive Study of prenatal and perinatal events and their association with the development of autistic spectrum disorders at a child Neurology Clinic in Puerto Rico.  Rios J, Vazquez M, San Miguel L.

• XXIX Annual Research and Educational Forum-UPR School of Medicine -2010. Infantile Spasms: Case Series Review; Gonzalez J ,Vazquez M. Poster  .J. González M.D., and M. Vázquez

• XXIX Annual Research and Education Forum- UPR School of Medicine-2009  Poster:  Developmental Study on a Pediatric Cohort Diagnosed with neonatal seizures ; General Intelligence and Visuo-motor Function. Protocol#A2770107. San Miguel-Montes L, Vazquez M.

• XXVIII Annual Research and Education Forum- UPR School of Medicine-2008  Poster:  Clinical and Cognitive Profile of Puerto Rican Pediatric Patients: A Pilot Study. Ríos-Motta, M., San Miguel-Montes, L., Avilés, R., Duprey A., Ríos, J., Vázquez, M. 

• XXVIII Annual Research and Education Forum- UPR School of Medicine-2008 Poster; The educational And community impact of the development of a new Child Neurology Program in Puerto Rico.  Gonzalez B., Vazquez M. (2nd prize)

Publications:

• San Miguel-Montes, L., Avilés, R., Duprey A., Ríos, J., Vázquez, M.  Clinical and Cognitive Profile of Puerto Rican Pediatric Patients: A Pilot Study. Ríos-Motta, M., PRHSJ Vol. 27 No. 3, p.282, September, 2008.

• B Gonzalez, M Vazquez. The educational And community impact of the development of a new Child Neurology Program in Puerto Rico .PRHSJ Vol. 27 No. 3,  September, 2008.

• Isenberg, Vázquez. Are the pupil of the premature infant affected by Intraventricular hemorrhage?       Journal of Child Neurology Vol 9 Num 4 440-442 , October 1994

• Isenberg Molarte, Vázquez .The fixed and dilated pupil of the premature neonate. Am Journal of Opthalmology 110; 168-171. August 1990.

• Fernandez Sein, Vázquez Correa.  Hypokalemic Periodic Paralysis: A rarely considered diagnosis in the Pediatric Patient  PR Medical Association Bulletin Vol7 Num2  1985

• Vazquez Calzada, Vázquez Correa. Cuidado Prenatal en Puerto Rico .Revista Salud Publica.Vol 4 1982-1983

María Dávila, M.D.

Academic Rank:

Assistant Professor,
School of Medicine,
University of Puerto Rico
Administrative title: Associate Program Director            

Office Address:

Hospital Dr. Antonio Ortiz
Pediatric Department,
Call Box 191079,
San Juan, PR 00919-1079                                                                                                   
Phone: 787-756-4020                                                                                                     

Email: maria.davila6@upr.edu

Research interest: CNS Demyelinating Disorders in children

Research in progress:

"The clinical and prognostic factors for relapse after acute disseminated encephalomyelitis in children"

Research Projects Participation:

• 03/2006-03/2007   An Open-label multicentric study of the long-term safety of Depakote sprinkle capsules in the treatment of partial seizures in children, Co-investigator, San Juan City Hospital

• 2005-2007. Grant HRSA : For the development of Child Neurology Training Program in P.R. Position: Clinical Investigator (PI Dra. Gregory Health Department) .Source of funding; HRSA

Presentations:

• XXVII-Annual Forum Research and Educational Forum- UPR School of Medicine.  March 12-14, 2008. Poster:  Acute and Disseminated Encephalomyelitis: A Case series Report at the University Pediatric Hospital in Puerto Rico. M Davila, K Cruz, R Alvarado, B Gonzalez.

• XXX Annual Research and Education Forum- UPR School of Medicine March 2010 Poster:  First Unprovoked Seizure: Correlation between Clinical Presentation and Findings on Brain MRI and EEG. B. González, MD; J.González, MD; M. Ríos, MD and M. Dávila, M.D.

• XXXI Annual Research and Education Forum- UPR School of Medicine May 2011  Poster: Treatment with Intensive Intravenous Immunoglobulin in Recurrent and Multiphasic Forms of Acute Disseminated Encephalomyelitis: Case Reports at the University Pediatric Hospital in Puerto Rico.  J González MD, and  M Dávila MD

Publications:

• González, B., González, J., Ríos, M., and Dávila, M. First Unprovoked Seizure: Correlation between Clinical Presentation and Findings on Brain MRI and EEG. PRHSJ Vol. 29 No. 2, June, 2010, p.166

Miriam E. Ríos, M.D.

Academic Rank: Assistant Professor,
School of Medicine,
University of Puerto Rico

Administrative Title: Director- Pediatric Epilepsy Clinic

Office Address:

Hospital Dr. Antonio Ortiz
Pediatric Department,
Call Box 191079,
San  Juan, PR 00919-1079                                                                                                     
Phone: 787-756-4020   
                                                                                                      
Email: miriam.rios@upr.edu

Research interest:

Epilepsy and EEG in children; Cognitive and psychiatric co-morbidities in children with epilepsy

Research in progress

New antiepileptic drug clinical trial

Presentations:

• American Epilepsy Society Annual Meeting, San Francisco, CA, December 1996.  Cortical stimulation mapping of right hemisphere language in patients with bilateral speech arrest during the intracarotid amobarbital procedure.  Ríos, M.; Hart, J.; Gordon, B.; Lesser, R.P.

• XXVIII Annual Research and Education Forum- UPR School of Medicine-2008 Poster:  Clinical and Cognitive Profile of Puerto Rican Pediatric Patients: A Pilot Study. Ríos-Motta, M., San Miguel-Montes, L., Avilés, R., Duprey A., Ríos, J.

• American Epilepsy Society Annual Meeting, Boston, MA, December 2009   Poster presentation: Depressive Symptoms in Adolescents with Epilepsy Attending the Epilepsy Clinic of the University Pediatric Hospital in Puerto Rico.  M Salcedo MD, M Ríos MD.                

• XXX Annual Research and Education Forum - UPR School of Medicine-March 2010 Poster: Prevalencia de síntomas de esquizofrenia en pacientes de una clínica de epilepsia en Puerto Rico. C. Morales-Rodríguez, R. Rios Motta, M. Ríos-Motta.  Escuela de Salud Pública, UPR-Recinto de Ciencias Médicas.

• XXX Annual Research and Education Forum- UPR School of Medicine March 2010 Poster: First Unprovoked Seizure: Correlation between Clinical Presentation and Findings on Brain MRI and EEG. B. González, MD; J.González, MD; M. Ríos, MD and M. Dávila.

Publications:

• Ríos, M.; Lenz, F.; Lesser, R.P.; Chau, D.; Laser evoked potentials recorded from the human cingulate cortex, (abstract); Proceedings of the 8th World Congress on Pain, pp. 441, 1996.

• Ríos, M.; Hart, J.; Gordon, B.; Lesser, R.P., Cortical stimulation mapping of right hemisphere language in patients with bilateral speech arrest during the intracarotid amobarbital procedure,(abstract); Epilepsia, Vol. 37, suppl. 5, pp. 132, 1996.

• Lenz, F.A. , Ríos, M. , Zirh, A. , Chau, D. , Krauss, G. , Lesser, R.P.  Painful stimuli evoked potentials recorded over the human anterior cingulate Gyrus.  Journal of Neurophysiology, 79:2231-2234, 1998.

• Lenz, F.A. , Ríos, M., Chau, D., Krauss, G., Zirh, A., and Lesser, R.P.  Painful stimuli evoke potentials recorded over the parasylvian cortex in humans.   Journal of Neurophysiology, 80:2077-2088, 1998.

• Ríos M. , Treede R.D., Lee J.-I., and Lenz, F.A.  Direct evidence of nociceptive input to human anterior cingulate gyrus and parasylvian cortex.  Current Review of Pain, 3:256-264, 1999. 

• Treede, R.D., Vogel, H., Ríos, M., Krauss, G., Lesser, R.P., Lenz, F.A. Pain-related evoked potentials from parasylvian cortex in humans.  Functional Neuroscience: Evoked Potentials and Magnetic Fields (EEG Suppl. 49): 250-254, 1999.

• Lenz, F.A., Krauss, G. , Treede R.D. , Lee, J.-I. , Boatman, D. , Crone, N., Minahan, R. , Port, J. , Ríos, M.  Different generators in human temporal-parasylvian cortex account for subdural laser-evoked potentials, auditory-evoked potentials, and event-related potentials.  Neuroscience Letters 279:153-1156, 2000.

• Lugo González, ME; Santos Ortiz, MC; Dávila Torres, RR; Ríos Motta, M.  Aspectos Relacionados al cumplimiento de medicamentos en un grupo de encargados de niños y adolescentes con epilepsia.  P R Health Sci J (Puerto Rico) Vol. 20 (3), p257-67; Sep. 2001.

• San Miguel-Montes, L., Avilés, R., Duprey A., Ríos, J., Vázquez, M.  Clinical and Cognitive Profile of Puerto Rican Pediatric Patients: A Pilot Study. Ríos-Motta, M., PRHSJ Vol. 27 No. 3, p.282, September, 2008.

• Salcedo, M., Ríos, M.   Depressive Symptoms in Adolescents with Epilepsy Attending the Epilepsy Clinic of the University Pediatric Hospital in Puerto Rico. Epilepsia, 50(Suppl. 11): p. 232, 2009

• Morales-Rodríguez, C., Rios Motta, R., Ríos-Motta, M.  Prevalencia de síntomas de esquizofrenia en pacientes de una clínica de epilepsia en Puerto Rico; PRHSJ Vol. 29 No. 2, June, 2010, p.162.

• González, B., González, J., Ríos, M., and Dávila, M. First Unprovoked Seizure: Correlation between Clinical Presentation and Findings on Brain MRI and EEG. PRHSJ Vol. 29 No. 2, June, 2010, p.166